Prions And Retroviruses – An Unholy Alliance? – Expression Of Endogenous Retroviruses Is Changed After Prion Infection
Medical News Today
In work originating from the Bavarian Research Cooperation Prions (FORPRION), which ended in 2007, a team led by the scientist Prof. Dr. Christine Leib-Mösch has been able to show that prion proteins may activate endogenous retroviruses in infected brain cells.
In the Institute of Molecular Virology of the GSF – National Research Center for Environment and Health in Neuherberg/Munich, Germany (Helmholtz Association of German Research Centres), the group is continuing to search for cellular components whose make-up is changed as a result of a prion infection. In collaboration with colleagues from the Technical University of Munich and the University of Heidelberg, the group used micro-array technologies – micro-arrays are chips with thousands or tens of thousands of DNA or protein probes – and could demonstrate that the expression of endogenous retroviruses is influenced by infectious prion proteins in tests with mouse cells.